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Keys confidently declares that fat in the diet leads to serum cholesterol and thus heart disease.

January 1, 1954


Diet-Heart Hypothesis

"No other variable in the mode of life besides the fat calories in the diet is known which shows anything like such a consistent relationship to the mortality rate from coronary or degenerative heart disease," he[Ancel Keys] told his colleagues at a gathering to discuss artheroschlerosis in 1954.

Big Fat Surprise -page 27