High Fructose Corn Syrup is produced for the first time after a new enzyme is invented.
HFCS was first produced by Richard O. Marshall and Earl R. Kooi in 1957 after they created the enzyme glucose isomerase. The enzyme rearranged the composition of glucose in corn syrup and made it into fructose.
HFCS is produced from corn that was milled into corn starch. Which is then turned into corn syrup. The glucose isomerase enzymes are then added to turn the some of the glucose in the corn syrup into fructose. Then you've got HFCS.