When the civilized food of intruding Europeans is introduced to native indigenous lands changing a nutritional revolution for the worse. This typically means white flour, sugar, corn, rice, cooking seed oils, and alcohol.
January 1, 1885
FUNCTIONAL AND INFLAMMATORY DISEASES OF THE STOMACH. BY SAMUEL G. ARMOR, M.D., LL.D.
Functional Dyspepsia (Atonic Dyspepsia, Indigestion).
The dietary treatment of dyspepsia was described: the diet, for instance, of bodily labor should consist largely of digestible nitrogenous food, and meat, par excellence, should be increased in proportion as muscular exercise is increased.
FUNCTIONAL AND INFLAMMATORY DISEASES OF THE STOMACH.
BY SAMUEL G. ARMOR, M.D., LL.D.
Functional Dyspepsia (Atonic Dyspepsia, Indigestion).
As a rule, the food should be such as will require the least possible exertion on the part of the stomach. Raw vegetables should be forbidden; pastries, fried dishes, and all rich and greasy compounds should be eschewed; and whatever food be taken should be eaten slowly and well masticated. Many patients digest animal better than vegetable food. Tender brown meats, plainly but well cooked, such as beef, mutton, and game, are to be preferred. Lightly-cooked mutton is more digestible than beef, pork, or lamb, and roast beef is more digestible than boiled. Pork and veal and salted and preserved meats are comparatively indigestible. Bread should never be eaten hot or fresh—better be slightly stale—and bread made from the whole meal is better than that made from the mere starchy part of the grain. Milk and eggs and well-boiled rice are of special value.
But to all these general dietetic rules there may be exceptions growing out of the peculiarities of individual cases. These should be carefully studied. The aged, for obvious reasons, require less food than the young; the middle-aged, inclined to obesity and troubled with feeble digestion, should avoid potatoes, sweets, and fatty substances and spirituous liquors; persons suffering from functional derangements of the liver should be put, for a time, on the most restricted regimen; while, on the contrary, the illy fed and badly-nourished require the most nutritious food that can be digested with comfort to the patient.
To these general predisposing causes may be added indigestion occurring in febrile states of the system. The cause here is obvious. In all general febrile conditions the secretions are markedly disturbed; the tongue is dry and furred; the urine is scanty; the excretions lessened; the bowels constipated; and the appetite gone. The nervous system also participates in the general disturbance. In this condition the gastric juice is changed both quantitatively and qualitatively, and digestion, as a consequence, becomes weak and imperfect—a fact that should be taken into account in regulating the diet of febrile patients. From mere theoretical considerations there can be no doubt that fever patients are often overfed. To counteract the relatively increased tissue-metamorphosis known to exist, and the consequent excessive waste, forced nutrition is frequently resorted to. Then the traditional saying of the justly-celebrated Graves, that he fed fevers, has also rendered popular the practice. Within certain bounds alimentation is undoubtedly an important part of the treatment of all the essential forms of fever. But if more food is crowded upon the stomach than can be digested and assimilated, it merely imposes a burden instead of supplying a want. The excess of food beyond the digestive capacity decomposes, giving rise to fetid gases, and often to troublesome intestinal complications. The true mode of restoring strength in such cases is to administer only such quantities of food as the patient is capable of digesting and assimilating. To this end resort has been had to food in a partially predigested state, such as peptonized milk, milk gruel, soups, jellies, and beef-tea; and clinical experience has thus far shown encouraging results from such nutrition in the management of general fevers. In these febrile conditions, and in all cases of general debility, the weak digestion does not necessarily involve positive disease of the stomach, for by regulating the diet according to the digestive capacity healthy digestion may be obtained for an indefinite time.
Exhaustion of the nerves of organic life strongly predisposes to the atonic forms of dyspepsia. We have already seen how markedly the digestive process is influenced by certain mental states, and it is a well-recognized fact that the sympathetic system of nerves is intimately associated with all the vegetative functions of the body. Without a certain amount of nervous energy derived from this portion of the nervous system, there is failure of the two most important conditions of digestion—viz. muscular movements of the stomach and healthy secretion of gastric juice. This form of indigestion is peculiar to [p. 441]the ill-fed and badly-nourished. It follows in the wake of privation and want, and is often seen in the peculiarly careworn and sallow classes who throng our public dispensaries. In this dyspepsia of exhaustion the solvent power of the stomach is so diminished that if food is forced upon the patient it is apt to be followed by flatulence, headache, uneasy or painful sensations in the stomach, and sometimes by nausea and diarrhoea. It is best treated by improving in every possible way the general system of nutrition, and by adapting the food, both in quantity and quality, to the enfeebled condition of the digestive powers. Hygienic measures are also of great importance in the management of this form of dyspepsia, and especially such as restore the lost energy of the nervous system. If it occur in badly-nourished persons who take little outdoor exercise, the food should be adapted to the feeble digestive power. It should consist for a time largely of milk and eggs, oatmeal, peptonized milk gruels, stale bread; to which should be added digestible nitrogenous meat diet in proportion to increased muscular exercise. Systematic outdoor exercise should be insisted upon as a sine quâ non. Much benefit may be derived from the employment of electric currents, and hydrotherapy has also given excellent results. If the indigestion occur in the badly-fed outdoor day-laborer, his food should be more generous and mixed. It should consist largely, however, of digestible nitrogenous food, and meat, par excellence, should be increased in proportion to the exercise taken. Medicinally, such cases should be treated on general principles. Benefit may be derived from the mineral acids added to simple bitters, or in cases of extreme nervous prostration small doses of nux vomica are a valuable addition to dilute hydrochloric acid. The not unfrequent resort to phosphorus in such cases is of more than doubtful utility. Some interesting contributions have been recently made to this subject of gastric neuroses by Buchard, Sée, and Mathieu. Buchard claims that atonic dilatation of the stomach is a very frequent result of an adynamic state of the general system. He compares it to certain forms of cardiac dilatation—both expressions of myasthenia. It may result from profound anæmia or from psychical causes. Mathieu regards mental depression as only second in frequency. Much stress is laid upon poisons generated by fermenting food in the stomach in such cases. It may cause a true toxæmia, just as renal diseases give rise to uræmia. Of course treatment in such cases must be addressed principally to the general constitution.
But of all predisposing causes of dyspepsia, deficient gastric secretion, with resulting fermentation of food, is perhaps the most prevalent. It is true this deficient secretion may be, and often is, a secondary condition; many causes contribute to its production; but still, the practical fact remains that the immediate cause of the indigestion is disproportion between the quantity of gastric juice secreted and the amount of food taken into the stomach. In all such cases we have what is popularly known as torpidity of digestion, and the condition described is that of atony of the stomach. The two main constituents of gastric juice—namely, acid and pepsin—may be deficient in quantity or disturbed in their relative proportions. A certain amount of acid is absolutely essential to the digestive process, while a small amount of pepsin may be sufficient to digest a large amount of albuminoid food. [p. 442]Pure unmixed gastric juice was first analyzed by Bidder and Schmidt. The mean analyses of ten specimens free from saliva, procured from dogs, gave the following results:
Lack of the normal amount of the gastric secretion must be met by restoring the physiological conditions upon which the secretion depends. In the mean time, hydrochloric and lactic acids may be tried for the purpose of strengthening the solvent powers of the gastric secretion.
EXCITING CAUSES.—The immediate causes of dyspepsia are such as act more directly on the stomach. They embrace all causes which produce conditions of gastric catarrh, such as excess in eating and drinking, imperfect mastication and insalivation, the use of indigestible or unwholesome food and of alcohol, the imperfect arrangement of meals, over-drugging, etc.
Of exciting causes, errors of diet are amongst the most constantly operative, and of these errors excess of food is doubtless the most common. The influence of this as an etiological factor in derangement of digestion can scarcely be exaggerated. In very many instances more food is taken into the stomach than is actually required to restore tissue-waste, and the effects of such excess upon the organism are as numerous as they are hurtful. Indeed, few elements of disease are more constantly operative in a great variety of ailments. In the first place, if food be introduced into the stomach beyond tissue-requirements, symptoms of indigestion at once manifest themselves. The natural balance betwixt [p. 443]supply and demand is disturbed; the general nutrition of the body is interfered with; local disturbances of nutrition follow; and mal-products of digestion find their way into the blood. Especially is this the case when the excessive amount of food contains a disproportionate amount of nitrogenous matter. All proteid principles require a considerable amount of chemical alteration before they are fitted for the metabolic changes of the organism; the processes of assimilative conversion are more complex than those undergone by fats and amyloids; and it follows that there is proportional danger of disturbance of these processes from overwork. Moreover, if nitrogenous food is in excess of tissue-requirement, it undergoes certain oxidation changes in the blood without becoming previously woven into tissue, with resulting compounds which become positive poisons in the economy. The kidneys and skin are largely concerned in the elimination of these compounds, and the frequency with which these organs become diseased is largely due, no doubt, to the excessive use of unassimilated nitrogenous food. Then, again, if food be introduced in excess of the digestive capacity, the undigested portion acts directly upon the stomach as a foreign body, and in undergoing decomposition and putrefying changes frets and irritates the mucous membrane. It can scarcely be a matter of doubt that large groups of diseases have for their principal causes excess of alimentation beyond the actual requirements of the system. All such patients suffer from symptoms of catarrhal indigestion, such as gastric uneasiness, headache, vertigo, a general feeling of lassitude, constipation, and high-colored urine with abundant urates, together with varied skin eruptions. Such cases are greatly relieved by reducing the amount of food taken, especially nitrogenous food, and by a systematic and somewhat prolonged course of purgative mineral waters. Europe is especially rich in these springs. The waters of Carlsbad, Ems, Seltzer, Friedrichshall, and Marienbad, and many of the alkaline purgative waters of our own country, not unfrequently prove valuable to those who can afford to try them, and their value shows how often deranged primary assimilation is at the foundation of many human ailments. The absurd height to which so-called restorative medicine has attained within the last twenty years or more has contributed largely to the production of inflammatory forms of indigestion, with all the evil consequences growing out of general deranged nutrition.
The use of indigestible and unwholesome food entails somewhat the same consequences. This may consist in the use of food essentially unhealthy or indigestible, or made so by imperfect preparation (cooking, etc.). Certain substances taken as food cannot be dissolved by the gastric or intestinal secretions: the seeds, the skins, and rinds of fruit, the husks of corn and bran, and gristle and elastic tissue, as well as hairs in animal food, are thrown off as they are swallowed, and if taken in excess they mechanically irritate the gastro-intestinal mucous membrane and excite symptoms of acute dyspepsia, and not unfrequently give rise to pain of a griping character accompanied by diarrhoea. Symptoms of acute dyspepsia also frequently follow the ingestion of special kinds of food, such as mushrooms, shellfish, or indeed fish of any kind; and food not adapted to the individual organism is apt to excite dyspeptic symptoms. Appetite and digestion are also very much influenced by the life and [p. 444]habits of the individual. The diet, for instance, of bodily labor should consist largely of digestible nitrogenous food, and meat, par excellence, should be increased in proportion as muscular exercise is increased. For all sorts of muscular laborers a mixed diet is best in which animal food enters as a prominent ingredient. Thus, it has been found, according to the researches of Chambers, that in forced military marches meat extract has greater sustaining properties than any other kind of food. But with those who do not take much outdoor exercise the error is apt to be, as already pointed out, in the direction of over-feeding. It cannot be doubted at the present time that over-eating (gluttony) is one of our popular vices. Hufeland says: "In general we find that men who live sparingly attain to the greatest age." While preventive medicine in the way of improved hygiene—better drainage, better ventilation, etc.—is contributing largely to the longevity of the race, we unfortunately encounter in more recent times an antagonizing influence in the elegant art of cookery. Every conceivable ingenuity is resorted to to tempt men to eat more than their stomachs can properly or easily digest or tissue-changes require. The injurious consequences of such over-feeding may finally correct itself by destroying the capacity of the stomach to digest the food.
Food may also be introduced into the stomach in an undigestible form [p. 445]from defects of cookery. The process of cooking food produces certain well-known chemical changes in alimentary substances which render them more digestible than in the uncooked state. By the use of fire in cooking his food new sources of strength have been opened up to man which have doubtless contributed immeasurably to his physical development, and has led to his classification as the cooking animal. With regard to most articles the practice of cooking his food beforehand is wellnigh universal; and especially is this the case with all farinaceous articles of food. The gluten of wheat is almost indigestible in the uncooked state. By the process of cooking the starchy matter of the grain is not only liberated from its protecting envelopes, but it is converted into a gelatinous condition which readily yields to the diastasic ferments. Roberts, in his lectures on the Digestive Ferments, points out the fact that when men under the stress of circumstances have been compelled to subsist on uncooked grains of the cereals, they soon fell into a state of inanition and disease.
Animal diet is also more easily digested in the cooked than in the raw state. The advantage consists chiefly in the effects of heat on the connective tissue and in the separation of the muscular fibre. In this respect cooking aids the digestive process. The gastric juice cannot get at the albumen-containing fibrillæ until the connective tissue is broken up, removed, or dissolved. Hot water softens and removes this connective tissue. Hence raw meat is less easily digestible. Carnivorous animals, that get their food at long intervals, digest it slowly. By cutting, bruising, and scraping meat we to a certain extent imitate the process of cooking. In many cases, indeed, ill-nourished children and dyspeptics digest raw beef thus comminuted better than cooked, and it is a matter of observation that steamed and underdone roast meats are more digestible than when submitted to greater heat.
Some interesting observations have been made by Roberts on the effects of the digestive ferments on cooked and uncooked albuminoids. He employed in his experiments a solution of egg albumen made by mixing white of egg with nine times its volume of water. "This solution," says Roberts, "when boiled in the water-bath does not coagulate nor sensibly change its appearance, but its behavior with the digestive ferments is completely altered. In the raw state this solution is attacked very slowly by pepsin and acid, and pancreatic extract has no effect on it; but after being cooked in the water-bath the albumen is rapidly and entirely digested by artificial gastric juice, and a moiety of it is rapidly digested by pancreatic extract."
It is a mistake, however, to suppose that cooking is equally necessary for all kinds of albuminoids. The oyster, at least, is quite exceptional, for it contains a digestive ferment—the hepatic diastase—which is wholly destroyed by cooking. Milk may be indifferently used either in the cooked or uncooked state, and fruits, which owe their value chiefly to sugar, are not altered by cooking.
The object in introducing here these remarks on cooking food is to show that it forms an important integral part of the work of digestion, and has a direct bearing on the management of all forms of dyspepsia.
January 1, 1911
American physical education review. v.16 (1911)
Up to this time the athletes had lived a simple natural life in the open air, eating figs, cheese, porridge and meal cakes, with meat only occasionally. The introduction of a meat diet is ascribed to Pythagoras of Samos, a trainer of boxing and other sports. The object of a meat diet was to make weight, and to produce this bulk the trainer prescribed vast quantities of meat.
The high ideals of the poet, artist and philosopher kept athletics comparatively pure for a short time, but when the patriotic wave that followed the Persian war had spent its force, the decline in amateurism was rapid, and we enter the third period where too much competition begat specialization; specialization begat professionalism, and that in itself was death to true sport. Even the good athlete could not hope for success unless he put himself under a rigorous and prolonged course of training. The trainers had to concentrate on the preparation for single events. "The runner," says Socrates, "has over-developed his legs, the boxer his arms and shoulders."
Up to this time the athletes had lived a simple natural life in the open air, eating figs, cheese, porridge and meal cakes, with meat only occasionally. The introduction of a meat diet is ascribed to Pythagoras of Samos(c. 570 – c. 495 BC), a trainer of boxing and other sports. It was momentous in that it at once created an artificial distinction between the life of the athlete and the life of the ordinary man, who ate meat but sparingly, just as our training tables place the athletes in an artificial and unnatural class by themselves, being used for this purpose quite as much as for any special diet that may be prescribed.
The object of a meat diet was to make weight, for there was no classification in Greece of boxers and wrestlers into light, middle, and heavy weights. Weight then was important, and to produce this bulk the trainer prescribed vast quantities of meat, so that eating, sleeping and exercise occupied the athlete's entire time.
Euripides calls such an athlete "the slave of his jaw and his belly," and the generals and soldiers condemned this training because it left no time for the practice of military exercises, and failed to produce the all-round development necessary for the useful soldier and citizen. The sacrifice for supreme excellence in a specialty was too great to make success a sufficient reward. Athletics had now passed that point where they could serve their true purpose of providing exercise or recreation. The competition was too severe and the training too artificial and exacting. It became the monopoly of the few professionals who devoted their entire time to it, while the rest of the young men, despairing of success, took to the hill as spectators. The amateur could not compete with the professional. Before the close of the fifth century, the word athlete had come to denote a professional, and amateur athletics were no longer practiced by the fashionable youth of Athens. Socrates, taunting an ill-developed youth with his unprofessional condition of body, meets the answer, "Of course, for I am not a professional but an amateur."
Whereupon Socrates reads him a lecture on the necessity of developing his body to the utmost, saying: "No citizen has a right to be an amateur in the matter of physical training. It is a part of his profession as a citizen to keep himself in good condition and ready to serve his state at amoment's notice." "What a disgrace it is for aman to grow old without ever seeing the beauty and strength of which his body is capable."
Fun Wikipedia Facts about Pythagoras:
Pythagoreanism also entailed a number of dietary prohibitions. It is more or less agreed that Pythagoras issued a prohibition against the consumption of fava beans and the meat of non-sacrificial animals such as fish and poultry. Both of these assumptions, however, have been contradicted. Pythagorean dietary restrictions may have been motivated by belief in the doctrine of metempsychosis. Some ancient writers present Pythagoras as enforcing a strictly vegetarian diet.[e] Eudoxus of Cnidus, a student of Archytas, writes, "Pythagoras was distinguished by such purity and so avoided killing and killers that he not only abstained from animal foods, but even kept his distance from cooks and hunters." Other authorities contradict this statement. According to Aristoxenus, Pythagoras allowed the use of all kinds of animal food except the flesh of oxen used for ploughing, and rams. According to Heraclides Ponticus, Pythagoras ate the meat from sacrifices and established a diet for athletes dependent on meat.
January 1, 1954
Observations on Blood Pressure in Eskimos
When comparing the Eskimo men with white men of corresponding age, it is observed that both the systolic and diastolic blood pressures are lower in Eskimos than in Whites. It appears to be the impression of most physicians who have had occasion to examine large numbers of Eskimos, that the blood pressure in Eskimos is lower than in normal Whites of corresponding age.
It appears to be the impression of most physicians who have had occasion to examine large numbers of Eskimos, that the blood pressure in Eskimos is lower than in normal Whites of corresponding age (P. B. Haggland, M. D. , E. S. Rabeau, M. D. , and E. Albrecht, M. D. , personal communications). Abnormally elevated blood pressures (systolic blood pressure in the order of 170 mm or higher) are apparently quite rare. Thus, in the 213 Eskimo patients who were subject to medical examination by the author during a two-year period in Alaska, the blood pressure was measured in 1 17 cases, and only one of the patients had systolic blood pressure above 145 mm.
In contrast to this, Saxtorph (quoted by A. Bertelsen, 1940) reported in 1926 that he had seen a considerable number of cases of hypertensio arterial is, both in old and middle-aged Greenland Eskimos. In 12 cases he measured blood pressures between 200 and 240 mm.
Thomas ( 1927) on the other hand examined 142 Greenland Eskimos, 40-60 years of age, and found the average blood pressure to be 129/76 mm, with a single case of 170/ 1 00. He concluded that hypertension with associated complications is extremely rare among Eskimos.
Holbeck (quoted by Bertelsen, 1940) has reported that the average systolic blood pressure in Greenland Eskimos, between 40 and 55 years uf age, was 141 in men and 131 in women. According to Bertelsen ( 1940) Svendsen examined, in 1930, the blood pressure of 106 Eskimos taken at random, some of whom had active pulmonary tuberculosis. He made the following findings: 15-30 years of age: 120/70 mm; 30-50 years ()f age: 137/77 mm; 50 years of age or over: 167/82 mm. Bertelsen (1940) concludes, on the basis of his experiences in Greenland, that the average blood pressure does not appear to deviate from that of Whites of corresponding age.
Probably the most extensive study of Eskimo blood pressure has been reported by Hoygaard (1941). He measured the blood pressure systematically of 283 Angmagssalik Eskimos, South East Greenland, of both sexes, living on their primitive diet, using the standard technique in lying or sitting position at least one hour after exercise. He found no material difference between males and females. Twelve persons out of 283 (4%) had a systolic blood pressure of 150 or higher; only two subjects had as much as 168 mm Hg. (Table 1). He concludes that hypertonia is not common.
According to MacMillan ( 1951) Or. E. Morse found no instance of high blood pressure among the Thule Eskimos during the Bowdoin's voyage to Greenland in 1950.
In the case of Canadian Eskimos, Brown (1 951) states with regard to the Southampton Island and the Igloolik Eskimos: "Arterial hypertension has also been found both in the group at Southampton Island and in the group at Igloolik." However, in the 63 Eskimos living in the vicinity of Chesterfield Inlet (30 males and 33 females) examined by Crile and Quiring ( 1939) the average blood pressure in the males (average age 38 years) was: systolic pressure 1 19 mm, diastolic pressure 75. In the females (average age 31 years) the figures were 1 12 and 72 respectively. The average pulse rate was 62-69 in the males and 79-82 in the females. These authors conclude that "the blood pressure for both the males and the females is lower than that of Whites of corresponding age, the pulse rate corresponds rather closely to that of White individuals".
Heinbecker (193 1) reports an average pulse rate of 64 in 5 Eskimos (4 females and 1 male, 15-50 years of age) from Baffin Island. Bollerud, et at. ( 1950) report an average pulse rate of 58 in their 23 male St. Lawrence Island Eskimos, 17--41 years old.
In connection with extensive studies on the patho-physiology of Eskimos which were in progress at the Arctic Aeromedical Laboratory as part of a survey of human adaptation to cold, we had an opportunity of recording various physical and physiological measurements during a two-year period 1950-1952. In this paper we are only concerned with blood pressure. pulse rate and age.
4. Results and Discussion.
The results from all 104 Eskimo subjects of both sexes are presented in Table 2. The average age is just over 29 years, but the ages vary widely from 3 to 75. However, of the 104 subjects, 73 were between 15 and 40 years old and only 13 were below 15 years.
From this table it is observed that the pulse rate at rest, when considering the mean figure for all observations in each subject, is 71 beats per minute, but the figures show considerable individual variations. If only the final reading is considered, the mean value is 67 beats per minute, ranging from 44 to 120. The average systolic and diastolic blood pressures in Eskimos of both sexes, when considering the mean values of all readings in each subject, were 110 and 71 respectively. The mean values of the final blood pressure readings obtained when the lower level was established after several repeated examinations, were slightly less, the systolic pressure being 107 and the diastolic pressure 69. The range of these measurements is considerable.
Thus the resting systolic blood pressure varies from a minimum value of 84 to a maximum value of 140; the diastolic blood pressure varies from 56 to 100. Only one subject, a 14-year old boy, showed as high an average value for the systolic blood pressure as 140. No systolic blood pressure higher than 162 mm was recorded in this series. 80.76 o/c of the recorded systolic blood pressures were below 116 mm.
Table 3 shows the results of similar measurements in 40 normal white men examined in Alaska by the same investigator. In this material the average age is 23 years. It appears that the figures for pulse rate are very similar to the corresponding figures for Eskimos. The mean figures for blood pressure are higher than in the Eskimos, both in the case of systolic and diastolic pressure, and in the case of both the mean values of all observations as well as in the case of the final values, recorded when the lower level had been established as the result of repeated examinations. It is observed that the figures, both for pulse rate and blood pressure in these White subjects, are lower than the figures published by McKiniay and Walker (1935) for 566 normal white men with a mean age of 23.2 years. The difference is over 5 times the standard error, both in the case of pulse rate and blood pressure.
The wide range of "normal" variations in blood pressure in Whites, has been emphasized by McKinlay and Walker (1935). According to American sources the average values for systolic pressure in healthy males, as measured in the brachial artery with the individual at rest, vary from 100 to 120 in early manhood, from 125 to 136 in the middle years of adult life, and from 145 to 150 above the age of sixty years.
The range of individual measurements. however, may show much wider variations. Alvarez, quoted by McKinlay and Walker (1935), found that the systolic blood pressure in 6,000 University students and graduates between the ages of 16 and 40 years may be as low as 85 mm or as high as 190 mm. He concludes that 22 per cent of men have a systolic blood pressure exceeding 140 mm and that one man in every forty has Cl systolic blood pressure higher than 160 ml. According to Diehl and Sutherland (1925), nine per cent of male students, 16-40 years of age, at the University of Minnesota had blood pressures over 140 mm. None of our Eskimo men, 15-40 years old. had mean blood pressures over 140 ml.
As a rule, the lowest blood pressure readings were obtained at the fourth examination in Whites, but ne,t until the fifth examination in Eskimos.
McKinlay and Walker (1935) had examined the variability and interrelationship of heart rate, systolic and diastolic blood pressure, pulse pressure and age in healthy men of ages ranging from 16 to 40. They conclude that within the period of life studied, age is not of great importance in determining the level of any of these factors. They find definitely significant, positive relationship between age and both systolic and diastolic blood pressure. but in such a degree as to form anything like a reasonably accurate basis for prediction. They find positive, but not very intimate, association between heart rate and blood pressure.
In Tables 4, 5 and 6 our data are separated into three age groups: 15-25 years, 26-40 years, and over 40 years old.
Twenty-five of the male Eskimos were between 15 and 25 years old. the average age being slightly over 21 years in this group. The same number of male Eskimos fell in the second age group: 26-40 years, the average age in this group being 33 years. Only twelve of the male Eskimo subjects were over 40 years old.
There is no difference in the mean value of all readings in each subject for the 15-25-year-old group as compared with the 26-40- year-old group, but the mean value for the group over 40 years old is higher than the first two groups. The difference is 4 times the standard error, and is therefore probably statistically significant.
The data for the 29 Eskimo women, divided into the three age groups: 15-25 years old (12 subjects), 26-40 years old (11 subjects), and over 40 years old (6 subjects), are given in Table 5. On the basis of this limited material it appears that the average blood pressure in Eskimo women is somewhat higher than in Eskimo men, but this difference is not statistically significant. There is also a tendency towards increased blood pressure with increasing age in Eskimo women.
Of the 40 white men, 34 fell into the first age group (15-25 years) and 5 in the second age group (26-40 years) while only one subject was over 40 years old. If we compare these white men with Eskimo men of corresponding age, it is observed that the average blood pressure is slightly higher in Whites than in Eskimos but the difference is too small to be significant statistically (less than 3 times the standard error). The mean of the lowest measured blood pressure in each subject in the first age group is considerably lower in Eskimos than in Whites, however. The difference is about 4 times the standard error, and may be statistically significant. The number of subjects is too small, nevertheless, to allow any definite conclusion to be drawn from this material.
It should also be noted that a larger proportion of the blood pressure measurements were recorded in the lying position in the Eskimos (70 C,c) than is the case in the Whites (25 o/c) and since the blood pressure tends to be lower in the lying position (Tables 7 and 8), this may partly account for the difference, although the difference between sitting and lying blood pressure in Whites in this material is not significant statistically. Thus, in Whites 15-25 years old, the difference between the means for sitting and lying systolic blood pressure is 5 mm, which is less than twice the standard error, as is also the case when comparing the diastolic blood pressure in the sitting and lying position. However, out of the 24 lowest measured blood pressures in Whites 15-25 years old, 76.47 per cent were measured in the lying pOSitIOn, and of the highest measured blood pressures in the same subjects, 97.06 per cent were measured in the sitting position. It may be noted however that in Eskimos the difference between sitting and lying blood pressure is about 3 times the standard error.
In Whites 15-25 years old, the mean pulse rate is 72 measured sitting, and only 58 when measured lying. The difference is 4 times the standard error, and may therefore be considered significant in a statistical sense, although the number of observations is very small. The range of the pulse rate measured sitting is 68-86, against 51-67 measured lying.
From Table 10 it appears that the Kotzebue and Gambell Eskimos in the age group 26-40 years have a lower mean blood pressure than the corresponding age groups from Anaktuvuk Pass and Barter Island. The difference between the Gambell and the Anaktuvuk Pass groups (the groups showing the most pronounced difference), as regards the means of the lowest measured blood pressures, is 12 mm, and the standard error is 3.20. Thus, the difference is over three times the standard error. However, the material is too small to allow any conclusion. No significant difference was detected in the blood pressure in Eskimos 15 -25 years old from the 4 different settlements (Table 9).
5. Summary and Conclusion.
735 blood pressure and pulse rate measurements were made in a consecutive series of 104 Eskimos (75 males and 29 females) from 4 different Eskimo settlements in Alaska. Similar measurements were made in 40 normal white men for comparison.
In Eskimos the mean resting systolic blood pressure varied from a minimum value of 84 to a maximum value of 140. No systolic blood pressure higher than 162 mm was ever recorded in our Eskimo subjects. 80 o/c of the recorded systolic blood pressures were below 1 16 mm. The mean diastolic blood pressures varied from 56 to 100. In Eskimos the mean blood pressure is somewhat higher in women than in men of corresponding age although the difference is not statistically significant, and there is a tendency towards increased blood pressure with increasing age.
In Eskimo men the mean blood pressure was 108/69 at ages 15-40 years, and 119/77 above 40 years of age. In Eskimo women the figures were 111/71 and 122 /74 respectively. When comparing the Eskimo men with white men of corresponding age, it is observed that both the systolic and diastolic blood pressures are lower in Eskimos than in Whites. This difference appears to be statistically significant in the case of the lowest measured blood pressure in each subject in the two groups. The mean pulse rates in Eskimos at rest were not materially different from the corresponding figures for Whites.